“He is in a race the place his immune system is racing in opposition to the virus, and if the virus wins you possibly can have dire penalties, clearly, and what our antibodies do is we make it a good battle,” Dr. Leonard Schleifer advised CNN’s Wolf Blitzer.
“He is in the next threat group for quite a lot of causes similar to being older, and if we give our antibodies, we hope that we are going to give his immune system sufficient of a lift in order that he can win this and make an entire restoration,” Schleifer stated.
Regeneron’s experimental monoclonal antibody remedy remains to be in large-scale scientific trials, however is offered for compassionate use, one thing the US Meals and Drug and Administration has to approve on a person foundation.
Trump acquired a single eight gram dose of Regeneron’s twin antibody cocktail Friday and accomplished the infusion with out incident, the President’s doctor, Dr. Sean Conley, stated in an announcement.
“Along with the polyclonal antibodies, the President has been taking zinc, vitamin D, famotidine, melatonin and a every day aspirin,” Conley stated.
A single high-dose of Regeneron’s antibody remedy ought to do the trick, Schleifer stated.
“It is a big sufficient dose, so that it will final for fairly a very long time, hopefully even past when he is made an entire restoration,” he stated. “We’ve proof prepared that these are lengthy lasting within the physique, as you’d count on with one of these remedy.”
The cocktail contains two monoclonal antibodies—lab-engineered variations of immune system proteins focused particularly in opposition to coronavirus.
“It isn’t all that sophisticated. We’re simply making an attempt to imitate the pure immune system, which actually is not able to go when the virus is already going,” Schleifer stated.
Issues about experimental antibody remedy
However an emergency drugs physician at Brigham and Ladies’s Hospital in Boston, Dr. Jeremy Faust, has been outspoken about giving the President an unapproved remedy.
“We do not give this treatment out, not since you’re not particular sufficient to get it, (however) as a result of we do not but know,” he stated.
“We do a threat and profit evaluation of all the things and if I am unable to inform my affected person what the profit is, there is no dialog available,” Faust advised CNN.
He additionally stated giving the unproven remedy to Trump simply does not look good.
“This isn’t prepared for prime time and, fairly frankly, it sends a message that they are scrambling,” Faust stated.
Different sufferers might search the identical remedy, he stated.
“I am unable to look them within the eye and inform them that I do know something about it, when it comes to its dangers and advantages. That is a fairly dangerous precedent,” Faust stated.
Regeneron says outcomes are promising
And the previous director of the US Facilities for Illness Management and Prevention, Dr. Thomas Frieden, agreed.
Regeneron’s experimental monoclonal antibody remedy to deal with the coronavirus, though it is unproven, is “a promising remedy,” stated Frieden, the CEO of the well being initiative Resolve to Save Lives.
“We do not know if it will be useful, however it’s one thing that’s not unreasonable to strive,” he stated.
“There is a report that solely fewer than 300 sufferers have acquired it. It appears to be best early within the illness, particularly earlier than sufferers make antibodies of their very own.”
Trump, who was admitted to Walter Reed Nationwide Navy Hospital Friday night, acquired the monoclonal antibody remedy earlier within the day, however Schleifer wouldn’t affirm whether or not first woman Melania Trump had additionally acquired the remedy.
Jen Christensen contributed to this story.